21 Amyloidosis
- clump of proteins in extracellular space of tissues
- lots and lots of different amyloid proteins that can accumulate
- common features of all amyloid
- biopsy similar to other proteins, use stain
Systemic
Transthyretin
- transports thyroid: transthyretin
- ATTR: name for amyloidosis with transthyretin
- cardiac form of amyloidosis
AL
AA
- secondary amyloidosis: occurs secondarily to inflammation
- Acute phase reactants: levels elevated in inflammation
Familial Mediterranean Fever
- in mediterranean countries
- serosal surfaces, abdomen, mimic appendictis
- neutrophil disorder
Dialysis
Symptoms by organs
- brain: Alzheimer
- pancreas: type 2 diabetes, amylin
- thyroid: medullary carcinoma, calcitonin deposition
- common with AL and age related
Backlinks